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Find MND Biomarker

Find MND Biomarker

Find MND Biomarker

Find MND Biomarker

Welcome to FindMNDBiomarker, an integrative database that consolidates the proteomic findings in brain tissue and biofluids (CSF and blood) from patients with motor neuron disease (also known as amyotrophic lateral sclerosis). FindMNDBiomarker is designed for users to quickly assess whether their proteins of interest have been identified in other cohorts and biosamples from patients with MND/ALS.

Purpose: The goal of this search platform is to facilitate the comparison and discovery of proteins that may serve as promising and reproducible biofluid biomarkers of brain-specific changes in MND/ALS and to identify markers that should be further targeted for analyses and validation.

Using this database: Searches can be performed by entering the protein UniProt IDs, names and sample types into the relevant search term box using free text entry. For example, entering ‘NEFL’ will generate a list of all publications in which NEFL was identified to be significantly dysregulated.

A searchable and filterable table is provided with the following columns:

  • Name: Gene name corresponding to the UniProt ID
  • UniProt ID: UniProt accession number
  • Publication: Study Reference
  • Condition: e.g.ALS – Control, ALS Fast – ALS Slow
  • Sample Type: Sample type used (Abbreviations: SMNs, single motor neurons; AH, anterior horn; PH, posterior horn)
  • Regulation: Direction of change (upregulated or downregulated)
  • Cohorts: Cohort size used for each study
  • Average age at onset ± standard deviation/age range: Average age at onset of ALS cohorts with standard deviation or age range (if provided by publication)
  • Average age at collection ± standard deviation/age range: Average age at collection of ALS cohorts with standard deviation or age range (if provided by publication)
  • Average PMI (range) (hours): Average postmortem interval with range (if provided by tissue studies)

To cite this database: Further details and application of this search tool are described in our manuscript “title” that can be located with this DOI: _____

Contact: For help contact rachel.tan1@sydney.edu.au
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Total Records Found: 4143, showing 100 per page
Biomarker NameUniProt IDPublicationDisease GroupComparator GroupSample TypeRegulationCohortsAverage age at onsetAverage age at collectionAverage PMI
CLTA P09496 Leoni et al. 2019 BO-ALS LO-ALS Plasma Down 14 BO-ALS, 16 LO-ALS (45-85) (BO-ALS), (40-76) (LO-ALS) N/A N/A
CLSTN1 O94985 Leoni et al. 2019 BO-ALS LO-ALS Plasma Down 14 BO-ALS, 16 LO-ALS (45-85) (BO-ALS), (40-76) (LO-ALS) N/A N/A
CLIP2 Q9UDT6 Iridoy et al. 2018 ALS Control Spinal cord (AH) Down 9 ALS, 8 control 57.6 62.8 N/A
CLIP1 P30622 Oeckl et al. 2020 ALS Control Spinal cord Up 8 ALS, 7 control N/A 59 (52-61) 36 (24-90)
CLIC4 Q9Y696 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CLIC4 Q9Y696 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CLIC1 O00299 Iridoy et al. 2018 ALS Control Spinal cord (AH) Up 9 ALS, 8 control 57.6 62.8 N/A
CLEC3B P05452 Vilardo et al. 2024 ALS (discovery cohort) Control (discovery cohort) Plasma EVs Down 61 ALS, 30 control N/A 62.88 ± 12.60 N/A
CLEC3B P05452 Zubiri et al. 2018 ALS fast (early stage) ALS slow (early stage) Plasma Down 6 ALS-fast, 6 ALS-slow 61.3 (48-67) (ALS-fast), 58.1 (35-71) (ALS-slow) N/A N/A
CLEC2L P0C7M8 Oeckl et al. 2020 ALS Control Spinal cord Down 8 ALS, 7 control N/A 59 (52-61) 36 (24-90)
CLCC1 Q96S66 Andrés-Benito et al. 2020 ALS Control CSF Down 15 ALS, 15 control N/A 61 ± 10.8 N/A
CLC Q05315 Leoni et al. 2019 BO-ALS LO-ALS PBMCs Down 12 BO-ALS, 12 LO-ALS (39-76) (BO-ALS), (33-81) (LO-ALS) N/A N/A
CLASP2 E7EW49 Iridoy et al. 2018 ALS Control Spinal cord (AH) Down 9 ALS, 8 control 57.6 62.8 N/A
CKMT2 P17540 Oeckl et al. 2020 ALS Control Spinal cord Down 8 ALS, 7 control N/A 59 (52-61) 36 (24-90)
CKMT2 P17540 Seyfried et al. 2018 ALS Control Prefrontal cortex Up 8 ALS, 8 control 60 63.5 9.1
CKMT1A P12532 Iridoy et al. 2018 ALS Control Spinal cord (AH) Down 9 ALS, 8 control 57.6 62.8 N/A
CKM P06732 Katzeff et al. 2020 ALS Control Serum Up 28 ALS, 22 control N/A 52.7 N/A
CKB P12277 Oeckl et al. 2020 gALS Control CSF Up 14 gALS, 16 control 54 (52-69) 62 (53-75) N/A
CKB P12277 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CKB P12277 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CKB P12277 Oeckl et al. 2020 sALS Control CSF Up 12 ALS, 16 control 66 (57-68) 67 (58-74) N/A
CKB P12277 Leoni et al. 2019 BO-ALS LO-ALS Plasma Up 14 BO-ALS, 16 LO-ALS (45-85) (BO-ALS), (40-76) (LO-ALS) N/A N/A
CKAP4 Q07065 Leoni et al. 2019 BO-ALS LO-ALS PBMCs Up 12 BO-ALS, 12 LO-ALS (39-76) (BO-ALS), (33-81) (LO-ALS) N/A N/A
CISD1 Q9NZ45 Seyfried et al. 2018 ALS Control Prefrontal cortex Down 8 ALS, 8 control 60 63.5 9.1
CIRBP Q14011 Leoni et al. 2019 BO-ALS LO-ALS PBMCs Up 12 BO-ALS, 12 LO-ALS (39-76) (BO-ALS), (33-81) (LO-ALS) N/A N/A
CHST6;CHST5 Q9GZX3 Oeckl et al. 2020 sALS Control CSF Up 12 ALS, 16 control 66 (57-68) 67 (58-74) N/A
CHST6 Q9GZX3 Oeckl et al. 2020 gALS Control CSF Up 14 gALS, 16 control 54 (52-69) 62 (53-75) N/A
CHST6 Q9GZX3 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CHST3 Q7LGC8 Oeckl et al. 2020 gALS Control CSF Up 14 gALS, 16 control 54 (52-69) 62 (53-75) N/A
CHST3 Q7LGC8 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CHST3 Q7LGC8 Oeckl et al. 2020 sALS Control CSF Up 12 ALS, 16 control 66 (57-68) 67 (58-74) N/A
CHST3 Q7LGC8 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CHST15 Q7LFX5 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CHST15 Q7LFX5 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CHST15 Q7LFX5 Oeckl et al. 2020 sALS Control CSF Up 12 ALS, 16 control 66 (57-68) 67 (58-74) N/A
CHST12 Q9NRB3 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CHST1 O43916 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CHRD Q9H2X0 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CHP1 Q99653 Englen-Lee et al. 2017 ALS Control Spinal cord (PH & AH) Up 10 ALS, 10 control 57.6 ± 10.9 62.6 ± 10.6 N/A
CHP1 Q99653 Seyfried et al. 2018 ALS Control Prefrontal cortex Up 8 ALS, 8 control 60 63.5 9.1
CHORDC1 Q9UHD1 Iridoy et al. 2018 ALS Control Spinal cord (AH) Down 9 ALS, 8 control 57.6 62.8 N/A
CHMP4B Q9H444 Iridoy et al. 2018 ALS Control Spinal cord (AH) Up 9 ALS, 8 control 57.6 62.8 N/A
CHMP4A Q9BY43 Hayashi et al. 2020 ALS Control CSF exosome-enriched fractions Down 3 ALS, 3 control N/A 74.3 N/A
CHMP2A O43633 Seyfried et al. 2018 ALS Control Prefrontal cortex Up 8 ALS, 8 control 60 63.5 9.1
CHL1 O00533 Vu et al. 2023 ALS fast ALS slow CSF Up 6 ALS-fast, 5 ALS-slow 54.3 (ALS-fast), 43.4 (ALS-slow) 55.3 (ALS-fast), 52.2 (ALS-slow)
CHIT1 Q13231 Dellar et al. 2023 ALS Healthy control CSF Up 40 ALS, 15 healthy control, 8 disease control 59.9 ± 12.2 61.8 ± 11.0 N/A
CHIT1 Q13231 Dellar et al. 2023 ALS Disease control CSF Up 40 ALS, 15 healthy control, 8 disease control 59.9 ± 12.2 61.8 ± 11.0 N/A
CHIT1 Q13231 Oh et al. 2023 ALS Control CSF Up 20 ALS, 20 control N/A 59 N/A
CHIT1 Q13231 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CHIT1 Q13231 Oeckl et al. 2020 gALS Control CSF Up 14 gALS, 16 control 54 (52-69) 62 (53-75) N/A
CHIT1 Q13231 Thompson et al. 2018 ALS Control CSF Up 43 ALS, 25 control 59.32 ± 10.9 61.9 ± 10.3 N/A
CHIT1 Q13231 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CHIT1 Q13231 Vu et al. 2023 ALS fast ALS slow CSF Up 6 ALS-fast, 5 ALS-slow 54.3 (ALS-fast), 43.4 (ALS-slow) 55.3 (ALS-fast), 52.2 (ALS-slow) N/A
CHIT1 Q13231 Oeckl et al. 2020 sALS Control CSF Up 12 ALS, 16 control 66 (57-68) 67 (58-74) N/A
CHI3L2 Q15782 Collins et al. 2015 ALS Control CSF Up 90 ALS, 80 control N/A N/A N/A
CHI3L2 Q15782-6 Bereman et al. 2018 ALS Control CSF Up 33 ALS, 30 control N/A N/A N/A
CHI3L2 Q15782 Oeckl et al. 2020 gALS Control CSF Up 14 gALS, 16 control 54 (52-69) 62 (53-75) N/A
CHI3L2 Q15782 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CHI3L2 Q15782 Thompson et al. 2018 ALS Control CSF Up 43 ALS, 25 control 59.32 ± 10.9 61.9 ± 10.3 N/A
CHI3L2 Q15782 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CHI3L2 Q15782 Oeckl et al. 2020 sALS Control CSF Up 12 ALS, 16 control 66 (57-68) 67 (58-74) N/A
CHI3L1 Q15782 Dellar et al. 2023 ALS Healthy control CSF Up 40 ALS, 15 healthy control, 8 disease control 59.9 ± 12.2 61.8 ± 11.0 N/A
CHI3L1 P36222 Bereman et al. 2018 ALS Control CSF Up 33 ALS, 30 control N/A N/A N/A
CHI3L1 P36222 Oeckl et al. 2020 gALS Control CSF Up 14 gALS, 16 control 54 (52-69) 62 (53-75) N/A
CHI3L1 P36222 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CHI3L1 P36222 Thompson et al. 2018 ALS Control CSF Up 43 ALS, 25 control 59.32 ± 10.9 61.9 ± 10.3 N/A
CHI3L1 P36222 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CHI3L1 P36222 Oeckl et al. 2020 sALS Control CSF Up 12 ALS, 16 control 66 (57-68) 67 (58-74) N/A
CHGA P10645 Andrés-Benito et al. 2020 ALS Control CSF Down 15 ALS, 15 control N/A 61 ± 10.8 N/A
CHGA P10645 Vu et al. 2023 ALS fast ALS slow CSF Down 6 ALS-fast, 5 ALS-slow 54.3 (ALS-fast), 43.4 (ALS-slow) 55.3 (ALS-fast), 52.2 (ALS-slow) N/A
CHCHD6 J3QTA6 Iridoy et al. 2018 ALS Control Spinal cord (AH) Down 9 ALS, 8 control 57.6 62.8 N/A
CHCHD3 C9JRZ6 Iridoy et al. 2018 ALS Control Spinal cord (AH) Down 9 ALS, 8 control 57.6 62.8 N/A
CHCHD2 Q9Y6H1 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CHAD O15335 Oeckl et al. 2020 ALS Control Spinal cord Down 8 ALS, 7 control N/A 59 (52-61) 36 (24-90)
CH3L2 Q15782 Oh et al. 2023 ALS Control CSF Up 20 ALS, 20 control N/A 59 N/A
CH3L1 P36222 Oh et al. 2023 ALS Control CSF Up 20 ALS, 20 control N/A 59 N/A
CH082 Q6P1X6 Andrés-Benito et al. 2020 ALS Control CSF Up 15 ALS, 15 control N/A 61 ± 10.8 N/A
CGREF1 Q99674 Chen et al. 2016 ALS Control CSF Up 35 ALS, 10 control N/A 52.7 ±12.13 N/A
CFP P27918 Zhou et al. 2023 SO-ALS Control CSF Down 4 BO-ALS, 5 SO-ALS, 5 control 63.25 ± 8.02 (BO-ALS), 51.2 ± 6.26 (SO-ALS) 64.25 ± 8.02 (BO-ALS), 52 ± 6.44 (SO-ALS) N/A
CFP P27918 Zhou et al. 2023 BO-ALS SO-ALS CSF Up 4 BO-ALS, 5 SO-ALS, 5 control 63.25 ± 8.02 (BO-ALS), 51.2 ± 6.26 (SO-ALS) 64.25 ± 8.02 (BO-ALS), 52 ± 6.44 (SO-ALS) N/A
CFL1 P23528 Barschke et al. 2020 C9-ALS C9-Control CSF Up 16 C9-ALS, 11 asymptomatic C9-controls N/A 60 (51-67) N/A
CFL1 G3V1A4 Zubiri et al. 2018 Late ALS (ALS slow cohort) Early ALS (ALS slow cohort) Plasma Up 6 ALS-fast, 6 ALS-slow 61.3 (48-67) (ALS-fast), 58.1 (35-71) (ALS-slow) N/A N/A
CFI P05156 Oeckl et al. 2020 gALS Control CSF Up 14 gALS, 16 control 54 (52-69) 62 (53-75) N/A
CFI P05156 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CFI E7ETH0 Zubiri et al. 2018 ALS fast (early stage) ALS slow (early stage) Plasma Down 6 ALS-fast, 6 ALS-slow 61.3 (48-67) (ALS-fast), 58.1 (35-71) (ALS-slow) N/A N/A
CFI G3XAM2 Bereman et al. 2018 ALS Control CSF Up 33 ALS, 30 control N/A N/A N/A
CFI P05156 Xu et al. 2018 ALS Control Plasma Up 42 ALS, 18 control N/A 61.8 ± 9.6 N/A
CFI P05156 Collins et al. 2015 ALS Control CSF Down 90 ALS, 80 control N/A N/A N/A
CFI P05156 Oeckl et al. 2020 sALS Control CSF Up 12 ALS, 16 control 66 (57-68) 67 (58-74) N/A
CFI E7ETH0 Vu et al. 2023 ALS fast ALS slow CSF Up 6 ALS-fast, 5 ALS-slow 54.3 (ALS-fast), 43.4 (ALS-slow) 55.3 (ALS-fast), 52.2 (ALS-slow) N/A
CFI G3XAM2 Leoni et al. 2019 BO-ALS LO-ALS Plasma Down 14 BO-ALS, 16 LO-ALS (45-85) (BO-ALS), (40-76) (LO-ALS) N/A N/A
CFHR4 Q92496 Oeckl et al. 2020 gALS Control CSF Up 14 gALS, 16 control 54 (52-69) 62 (53-75) N/A
CFHR4 Q92496 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CFHR2 P36980 Oeckl et al. 2020 gALS Control CSF Up 14 gALS, 16 control 54 (52-69) 62 (53-75) N/A
CFHR2 P36980 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CFHR2 Q03591 Vu et al. 2023 ALS fast ALS slow CSF Up 6 ALS-fast, 5 ALS-slow 54.3 (ALS-fast), 43.4 (ALS-slow) 55.3 (ALS-fast), 52.2 (ALS-slow) N/A
CFH P08603 Oeckl et al. 2020 gALS Control CSF Up 14 gALS, 16 control 54 (52-69) 62 (53-75) N/A
CFH P08603 Oeckl et al. 2020 ALS Control CSF Up 26 ALS, 16 control N/A N/A N/A
CFH P08603 Vu et al. 2023 ALS fast ALS slow CSF Up 6 ALS-fast, 5 ALS-slow 54.3 (ALS-fast), 43.4 (ALS-slow) 55.3 (ALS-fast), 52.2 (ALS-slow)
CFH P08603 Xu et al. 2018 ALS Control Plasma Up 42 ALS, 18 control N/A 61.8 ± 9.6 N/A